[
  {
    "id": "3N8HRWE7",
    "type": "article-journal",
    "abstract": "Prefrontal cortex (PFC) is postulated to exert \"top-down control\" on information processing throughout the brain to promote specific behaviors. However, pathways mediating top-down control remain poorly understood. In particular, knowledge about direct prefrontal connections that might facilitate top-down control of hippocampal information processing remains sparse. Here we describe monosynaptic long-range GABAergic projections from PFC to hippocampus. These preferentially inhibit vasoactive intestinal polypeptide-expressing interneurons, which are known to disinhibit hippocampal microcircuits. Indeed, stimulating prefrontal-hippocampal GABAergic projections increases hippocampal feedforward inhibition and reduces hippocampal activity in vivo. The net effect of these actions is to specifically enhance the signal-to-noise ratio for hippocampal encoding of object locations and augment object-induced increases in spatial information. Correspondingly, activating or inhibiting these projections promotes or suppresses object exploration, respectively. Together, these results elucidate a top-down prefrontal pathway in which long-range GABAergic projections target disinhibitory microcircuits, thereby enhancing signals and network dynamics underlying exploratory behavior.",
    "container-title": "Cell",
    "DOI": "10.1016/j.cell.2022.04.001",
    "ISSN": "1097-4172",
    "issue": "9",
    "journalAbbreviation": "Cell",
    "language": "eng",
    "note": "PMID: 35487191\nPMCID: PMC10027400",
    "page": "1602-1617.e17",
    "source": "PubMed",
    "title": "Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition",
    "volume": "185",
    "author": [
      {
        "family": "Malik",
        "given": "Ruchi"
      },
      {
        "family": "Li",
        "given": "Yi"
      },
      {
        "family": "Schamiloglu",
        "given": "Selin"
      },
      {
        "family": "Sohal",
        "given": "Vikaas S."
      }
    ],
    "issued": {
      "date-parts": [
        [
          "2022",
          4,
          28
        ]
      ]
    }
  }
]